Effect of Sodium Fluoride on the Transmural Potential Difference of the Rat Stomach
نویسنده
چکیده
Transmural potential difference (PD) was measured in vivo under continuous perfusion of the rat stomach. Lumina! NaF (5 mM) perfusion elicited a net temporal decrease of PD, whereas lower NaF concentrations (1 and 2 mM) had no effect. The fall of PD induced by 5 mM NaF was abolished at pH 8.4 and was enhanced (161%) at pH 3.2. Compared to NaF alone, the decrease of PD induced by the simultaneous perfusion of NaF and salicylic acid (5 mM each) was more pronounced (209%) with a previous perfusion of salicylic acid alone than the direct perfusion of NaF and salicylic acid (136%). These results suggest that the observed variations of PD reflect the early functional alterations of the mucosa preceding the structural damaging effects of hydrofluoric and salicylic acids.
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